information

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Phage therapy is influenced by:

Phage therapy is influenced by:

Country :
the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view

From Wikipedia


If the target host* of a phage therapy treatment is not
an animal the term "
biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

"In silico"

From:"Genomics,Proteomics and Clinical Bacteriology", N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.

Sunday 31 August 2014

Working hypothesis on Mycobacteriophage Receptors

 


 

If  mycobacteriophages L5, D29, Bxz2 and TM4  are capable to growth on Mycobaterium smegmatis MC2 155 and on Mycobacterium ulcerans then these mycobacteria must have the same receptor  or a different receptor for each of  these mycobacteriophage.


Phage..M.ulcerans Receptor (R1) ...M.smegmatis Receptor(R2)

L5..................... R1L5................................................ R2L5


D29................. R1D29.............................................. R2D29


Bxz2............... R1Bxz2............................................. R2Bxz2


TM4 ...............R1TM4.............................................. R2TM4


Suppositions:

M.ulcerans Receptor(R1) 

 
1)R1L5,R1D29,R1Bxz2,R1TM4 (the receptor is the same)
or
R1L5,R1D29,R1Bxz2,R1TM4 (the receptors are different one another).


M.smegmatis Receptor(R2)

 
2)R2L5,R2D29,R2Bxz2,R2TM4 (the receptor is the same)
or
R2L5,R2D29,R2Bxz2,R2TM4 (the receptors are different one another).


Combination:

3)R1L5,R1D29,R1Bxz2,R1TM4 and R2L5,R2D29,R2Bxz2,R2TM4 (the receptor is the same)
or
R1L5,R1D29,R1Bxz2,R1TM4 and R2L5,R2D29,R2Bxz2,R2TM4
(the receptors are different one another).