1-D29 is capable to lyse and to grow on Mycobacterium ulcerans
2- D29 is a L5likevirus,where the potential receptors are located in the tail fibers
3-D29 is a good model for the question regarding the type of receptor and the differences among the receptors because it is a lytic phage that infects both fast and slow- growing mycobaterial species
4- DS6A is capable to lyse and to grow only on mycobacteria belonging to Mycobacterium tuberculosis complex and this property give me the possibility to analyse the differences with D29.
From this scientific work:
From this scientific work :
" In 1981 Sula et al. reported positive indicators with a reduction in the observed lesions in the spleen, lungs and livers of guinea pigs following therapy with DS6A. More recent work demonstrated that phage therapy could have a beneficial effect in guinea pigs with disseminated tuberculosis, but that its action was considerably less pronounced than that of isoniazid monotherapy."
From this scientific work:
"Sula et al. [63] infected guinea pigs with M. tuberculosis and then treated them with subcutaneous injections of three different bacteriophages twice weekly for 10 weeks.
One of these bacteriophages, designated DS6A, produced an antibacterial effect at least as good as isoniazid."
From this scientific work:
"In addition, the previously isolated phage DS6A, the only one of the 138 phages that does not infect M. smegmatis was sequenced and annotated."
