Tuesday, 20 July 2010
In a patient whit cystic fibrosis disease the main obstacle, as a consequence of a biocontrol (phage therapy) treatment could be a possible dangerous developping reaction both to local level and/or to general level, caused by a massive release of endotoxin from lysed bacteria.
At moment we do not have data about this possible negative side effect by phage administration but in the Historical document (AD NUMBER AD837021)* is described a real application which does not provide any information about this question.
*"Aerosol treatment was administered every day. The duration of the individual sessions usually lasted 10-15 minutes. The average number of inhalations administered amounted to 11, the smallest number was 3 (this involved a subchronical tracheobronchitis), and the largest number was 40".
Herxheimer reaction
From:
Bacterial Endotoxin in Human Disease
If we want to avoid this side effect we must study a specific administration cycle for a patient with cystic fibrosis in terms of:
- Phage Dose
- Treatment Lenght
- Treatment Number
- Endotoxin Monitoring
My idea is to prepare a specific Phage cocktail and to add to this cocktail a proporzionate quantity of Polymyxin B* ( in this case the evaluations regarding the potential damages for toxicity by use of Polymyxin B must be made before all ).
Main Drug= Phages
LPS neutralizing= Polymyxin B
Polymyxin B is present for neutralizing the LPS that is released from phage- lysed bacteria.
Finally, after test, to use this synergetic composition by:
-aerosol therapy (Phages and Polymyxin B together or alternatively to use two close and separeted aerosol administrations, Phages before and Polymyxin B after )
or
-Phages by aereosol and Polymyxin B by hemoperfusion .
