There are two favourable points:
1°
Skin diseases are a good target for therapeutic treatments by phages.
key point : Phages are administrated by external application or by intradermal admnistration.
2°
Mycobacterium ulcerans induces the lysis of the infected host cells, becoming extracellular.
Mycobacterium ulcerans has been classified as an extracellular pathogen.
key point :Mycobacterium ulcer is vulnerable to attack by specific phages.
How we may decide when it is possible to initiate phage therapy in Buruli ulcer?
The probability of success must be higher if phage therapy initiates during the first phases of the disease.
In this work (and here)there are the guidelines ( drugs) to follow as potential indications.