information

Whoever comes in this website may find a hint

Phage therapy is influenced by:

Phage therapy is influenced by:

Country :
the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view

From Wikipedia


If the target host* of a phage therapy treatment is not
an animal the term "
biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

"In silico"

From:"Genomics,Proteomics and Clinical Bacteriology", N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.

Sunday, 13 July 2014

Is Phage Therapy possible in Buruli ulcer disease?


There are two favourable points:
Buruli ulcer is a severe necrotizing skin disease, characterized by the formation of large, painless necrotic ulcers in the absence of an acute inflammatory response.

Skin diseases are a good target for therapeutic treatments by phages.

key point : Phages are administrated by external application or by intradermal admnistration.

Mycobacterium ulcerans in biopsy specimens has been described as an extracellular bacillus
Mycobacterium ulcerans induces the lysis of the infected host cells, becoming extracellular.
Mycobacterium ulcerans has been classified as an extracellular pathogen.

key point :Mycobacterium ulcer is vulnerable to attack by specific phages.


How we may decide when it is possible to initiate phage therapy in Buruli ulcer?



 

The probability of success must be higher if phage therapy initiates during the first phases of the disease.
 

In this work (and here)there are the guidelines ( drugs) to follow as potential indications.