information

Whoever comes in this website may find a hint

Phage therapy is influenced by:

Phage therapy is influenced by:

Country :
the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view

From Wikipedia


If the target host* of a phage therapy treatment is not
an animal the term "
biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

"In silico"

From:"Genomics,Proteomics and Clinical Bacteriology", N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.

Thursday, 10 July 2014

Application Range of Phage Therapy

From the Phage Therapy Center (Tbilisi) Web site it is possible to find out the application range of Bacteriophage Therapy.
 

There is also a list of main Bacteria involved:

* Staphylococcus spp. (more than one species) including Methicillin Resistant Staphylococcus aureus (MRSA) and Community Associated Staphylococcus aureus (CA-MRSA).
* Streptococcus spp.
* Enterococcus spp.
* E. coli
* Proteus spp.
* Klebsiella pneumoniae
* Pseudomonas aeruginosa
* Several Other Bacterial Strains that are Emerging as Significant Challenges Even to the Most Advanced Antibiotics
* Infections Complicated with Candida and Other Yeast / Fungi

These Bacteria are involved in specific infections and in patological processes as:

-Chronic Infections
Antibiotics fail to cure many chronic infections because they are due to biofilms. Biofilms are complex mixtures of microbes that typically resist the effects of antibiotics:

* Chronic and Acute Urinary Tract Infections (UTI) and Cystitis
* Ear Infections (Otitis Media)
* Chronic Sinusitis (Rhinosinusitis)
* Skin Infections
* Intestinal Infections
* Prostatitis and Associated Sexual Problems


-Infections Where Circulation is Poor
Poor circulation makes it difficult to deliver the right concentration of antibiotics to the infected area. Such conditions include, but are not limited to, the following:

* Infected Wounds
* Osteomyelitis
* Diabetic Foot
* Tropic Ulcers
* Bed Sores


-Infections with Bacteria Resistant to Standard or Advanced Antibiotics




From F.A.Q

What is an autophage?
Bacteriophages are very specific to which species, and in many cases which strain, of bacteria that they will infect and destroy. The purpose of the initial laboratory test of a patient's bacterial sample is to determine if the bacteria are sensitive to the standard production phage preparations that are produced by our suppliers. If the bacteria are resistant to the phage preparations, then the production preparation will not be effective for treating the infection. The laboratory will, at the request of the patient, conduct a series of additional research, examining and testing with other phages in their collection, to determine if it is possible to develop a custom phage preparation for the patient's infection. Usually it is possible to develop an autophage, but there is no guarantee. This process is at additional cost, due to the labor involved.


What infections / conditions are not treatable with phage therapy?
There are a number of pathogens for which there are currently no therapeutic phage preparations available; the list includes:
  • Mycobacterium (all species, including tuberculosis)
  • Clostridium difficile
  • Citrobacter
  • Borrelia burgdorferi (Lyme Disease)
In many cases, however, Phage Therapy Center uses other similarly unique, safe and approved medical alternatives to treat many of the above species.