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Phage therapy is influenced by:
Phage therapy is influenced by:
Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view
Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view
From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".
"In silico"
From:"Genomics,Proteomics and Clinical Bacteriology", N.Woodford and Alan P.Johnson
Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.
Friday, 27 June 2014
Quorum Sensing
Quorum sensing is best characterized as a means of communication within a bacterial species, whereas competitive or cooperative signaling can occur between groups of bacteria or between bacteria and the host ( Gram-Negative bacteria,Gram-Positive bacteria and Biofilm).
Quorum sensing can be divided into at least 4 steps:
(1) production of small biochemical signal molecules by the bacterial cell; (2) release of the signal molecules, either actively or passively,into the surrounding environment; and (3) recognition of the signal molecules by specific receptors once they exceed a threshold concentration, leading to (4) changes in gene regulation.
One common consequence of quorum sensing induction of gene expression is increased synthesis of the proteins involved in signal molecule production. Increased synthesis of the signal molecule creates a positive feedback loop, which is why quorum signals are commonly called autoinducers.
From:
Bench-to-bedside review: Quorum sensing and the role of
cell to cell communication during invasive bacterial infection