Old post
Sunday, 11 July 2010
The six bacteriophage strains (which were deposited at the National Collection of Industrial and Marine Bacteria, 23 St Machar Drive, Aberdeen, AB24 3RY, Scotland, UK on 24 June 2003) :
Reference NCIMB Deposit
1- BC-BP-01 NCIMB 41174
2- BC-BP-02 NCIMB 41175
3-BC-BP-03 NCIMB 41176
4- BC-BP-04 NCIMB 41177
5- BC-BP-05 NCIMB 41178
6- BC-BP-06 NCIMB 41179
Veterinary Field Trial
A combined preparation of six bacteriophages was named BioVet-PA, and was authorized for trial in dogs with such infection by the Veterinary Medicines Directorate of the United Kingdom in November 2003.
Conduct of the Trial
BioVet-PA was stored at -80° C. Immediately prior to administration, the product was thawed and warmed in the hand 0.2 ml (containing 1x10^5 pfu by original titration of each of the 6 bacteriophages) was administered drop-wise using a sterile 1 ml capacity syringe into the ear. Ear condition and microbiology was assessed at 2 days post-administration.
Human Clinical Trial
This study investigated the efficacy and safety of BioPhage-PA, a mixture of six Pseudomonas aeruginosa bacteriophages of the same types as those tested as BioVet-PA in the veterinary field trial.
BIOPHAGE-PA