information

Whoever comes in this website may find a hint

Phage therapy is influenced by:

Phage therapy is influenced by:

Country :
the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view

From Wikipedia


If the target host* of a phage therapy treatment is not
an animal the term "
biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

"In silico"

From:"Genomics,Proteomics and Clinical Bacteriology", N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.

Monday, 20 October 2014

Close study of the poster "Pathogen eradication by phage therapy in patients wich chronic bacterial prostatitis"



Unfortunately for the moment the clinical cases  where  Phage therapy  is applied are infrequent.
For learning  it is inevitable to read the experience of others.

I start with a close study of this poster:


1-Disease (here):


 2-Methods:

-22 men with CBP and positive bacterial culture of expressed prostatic fluid (EPS)
- bacteria:
E.fecalis: n=16
E.coli: n=5
K.pneumoniae: n=2
P.aeruginosa: n=1
S.haemoliticus: n=1
-No presence of other micro-organisms (Chlamidia, Mycoplasma etc.)*
-No any drugs for at least one month
-measurement of the prostate size and of the urinary flow rate
- measurement of the index NIH-CPSI
-statistical  valuation





3-Phage treatment (year 2013):



 Comment:

Phage preparation is the same from:

here  ( year 1981)





Phage preparation is the same from:


here ( year 2000)

Phage preparation:



 4-Results:
 

Mean PT duration: 47 days 
Eradication in 50% of the cases
No side effects

  almost too easy!!