information

Whoever comes in this website may find a hint

Phage therapy is influenced by:

Phage therapy is influenced by:

Country :
the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view

From Wikipedia


If the target host* of a phage therapy treatment is not
an animal the term "
biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

"In silico"

From:"Genomics,Proteomics and Clinical Bacteriology", N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.

Wednesday, 29 October 2014

Now we all write about Phage therapy but where are the results?

The main target where there is a good chance of success for  phage therapy  is the skin  infection because  in this situation  there are few  adverse factors.


From
ClinicalTrials.gov


 



 The reasons are:
-easy medication
-easy check
- use of one Lytic Phage  or Phage cocktail
-direct contact with bacteria
-no antibodies
- easy to remove phage by washing
-et cetera


  In my old web site there is this document  from :



 
that now is unobtainable.





Comment:

 First we must   test  phage therapy in this  clinical area (and after in the others)


We must consolidate the theory but also to put it into the practice

It is  unsatisfactory to write  on Phage therapy only for publications

Why the PhagoBurn project is started ?   For the same reasons described above .



Monday, 20 October 2014

Close study of the poster "Pathogen eradication by phage therapy in patients wich chronic bacterial prostatitis"



Unfortunately for the moment the clinical cases  where  Phage therapy  is applied are infrequent.
For learning  it is inevitable to read the experience of others.

I start with a close study of this poster:


1-Disease (here):


 2-Methods:

-22 men with CBP and positive bacterial culture of expressed prostatic fluid (EPS)
- bacteria:
E.fecalis: n=16
E.coli: n=5
K.pneumoniae: n=2
P.aeruginosa: n=1
S.haemoliticus: n=1
-No presence of other micro-organisms (Chlamidia, Mycoplasma etc.)*
-No any drugs for at least one month
-measurement of the prostate size and of the urinary flow rate
- measurement of the index NIH-CPSI
-statistical  valuation





3-Phage treatment (year 2013):



 Comment:

Phage preparation is the same from:

here  ( year 1981)





Phage preparation is the same from:


here ( year 2000)

Phage preparation:



 4-Results:
 

Mean PT duration: 47 days 
Eradication in 50% of the cases
No side effects

  almost too easy!!

Saturday, 18 October 2014

IT 5210045 :Fiume Vigi ,a Special Area of Conservation (SAC) inside of the Sellano territory


Now is a  Special Area of Conservation by a law.


 Some animals  in this area:

 



From Wikipedia:

"A Special Area of Conservation (SAC) is defined in the European Union's Habitats Directive (92/43/EEC), also known as the Directive on the Conservation of Natural Habitats and of Wild Fauna and Flora. They are to protect the 220 habitats and approximately 1000 species listed in annex I and II of the directive which are considered to be of European interest following criteria given in the directive. They must be chosen from the Sites of Community Importance by the State Members and designated SAC by an act assuring the conservation measures of the natural habitat.
SACs complement Special Protection Areas and together form a network of protected sites across the European Union called Natura 2000. This, in turn, is part of the Emerald network of Areas of Special Conservation Interest (ASCIs) under the Berne Convention"
 
 
Seventh updated list of sites of Community importance for the Continental biogeographical region:




 Fiume Vigi





Thursday, 16 October 2014

One day, doctors might prescribe viruses instead of antibiotics



Here



Here


Current antibiotic-resistant threats in the U.S.




 Priority choice for  Phage therapy:


CRE bacteria infection: Carbapenem-Resistant Enterobacteriaceae
ESBLs :Extended spectrum beta-lactamase -producing Enterobacteriaceae
MRSA:Methicillin-resistant Staphylococcus aureus
VRSA:Vancomycin Resistant Staphylococcus aureus