Phage therapy subjects from Sellano town
information
Whoever comes in this website may find a hint
Phage therapy is influenced by:
Phage therapy is influenced by:
Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view
Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: a lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Chronolability
Mutation rate
Phenotypical delay
Phage cocktail
My point of view
From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".
"In silico"
From:"Genomics,Proteomics and Clinical Bacteriology", N.Woodford and Alan P.Johnson
Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.
Friday 13 July 2018
Wednesday 27 December 2017
Sunday 28 May 2017
Sunday 29 May 2016
Silk route to the acceptance and re-implementation of bacteriophage therapy
Link
My opinion:
phage preparation by genetic engineering is a time-consuming job and from realistic point of view it clashes with the rapidity of an appropriate antibacterial therapy (the patient could be in a danger situation and the action time could be short).
If in a country the constitution and the updating of a Bank for circulating natural lytic phages used in phage therapy is hard and expensive, the constitution and the updating of a Bank for genetic engineering phages used in phage therapy is very hard and very expensive.
The use of natural lytic phages may reduce these aspects.
My opinion:
phage preparation by genetic engineering is a time-consuming job and from realistic point of view it clashes with the rapidity of an appropriate antibacterial therapy (the patient could be in a danger situation and the action time could be short).
If in a country the constitution and the updating of a Bank for circulating natural lytic phages used in phage therapy is hard and expensive, the constitution and the updating of a Bank for genetic engineering phages used in phage therapy is very hard and very expensive.
The use of natural lytic phages may reduce these aspects.
Sunday 24 April 2016
Phage therapy is not for all bacterial infections
If we consider the work experience hoarded in the Ex-USSR countries about phage therapy such as a reference model and a good starting point then it is important does not forget that Phage therapy application can not diseregard from the following points:
1-Phage therapy is not for all bacterial infections.
2-It is necessary to make a priority list of all bacterial infections where Phage therapy could be effective.
In general terms Phage Therapy Efficacy follows a decreasing gradient in the recovery chances.
Both recovery results and Phage presence are linked to the anatomical Site where a bacterial Infection is localized and active.
This decreasing Efficacy Gradient starts from the infective processes on the external surface of the Body to the infective processes on the intestinal mucosa , urinary tract and in the end, to the infective processes reached by bloodstream only.
When the infection site is localized on the skin we may have the best recovery chance by Phage therapy .
3-Phage therapy must be a timely remedy and easy . It is important does not lose time. For this raison it is necessary to have a national data bank on circulating bacteria and for sending to the hospital lab corresponding phages ready for use.
4-Phage therapy requires only Phage cocktails. Phage cocktail must be well characterized and its effect monitored in the time.
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