Silk route to the acceptance and re-implementation of bacteriophage therapy

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My opinion:
phage preparation by genetic engineering  is a time-consuming job and from realistic point of view it clashes with the rapidity  of an appropriate antibacterial therapy (the patient could be in a danger situation and the action time could be short).

 

If in a country the constitution and the updating of a Bank for circulating natural lytic phages used in phage therapy  is hard and expensive, the constitution and the updating of a  Bank for genetic engineering phages used in phage therapy is very hard and very expensive.
The use of natural lytic phages may reduce  these aspects.

Phage therapy is not for all bacterial infections

If we consider the  work experience  hoarded in the Ex-USSR countries about phage therapy such as a reference model and a good starting point then it is important does not forget that Phage therapy application can not diseregard  from the following points:

1-Phage therapy is not for all bacterial infections.
2-It is necessary to make a priority list of  all bacterial infections where Phage therapy could be effective.
In general  terms Phage Therapy Efficacy follows a decreasing gradient in the recovery chances.
Both recovery results and Phage presence are linked to the anatomical Site where a bacterial Infection is localized and active.
This decreasing Efficacy Gradient starts from the infective processes on the external surface of the Body to the infective processes on the intestinal mucosa , urinary tract and in the end, to the infective processes reached by bloodstream only.
When the infection site is localized on the skin we may have the best recovery chance by Phage therapy .




3-Phage therapy must be a timely remedy and easy . It is important does not lose time. For this raison it is necessary to have a national data bank on circulating bacteria and for sending to the hospital lab corresponding phages ready for use.

4-Phage therapy requires only Phage cocktails.  Phage cocktail must be well characterized and its effect monitored in the time.

WHO: Buruli ulcer (Mycobacterium ulcerans infection) Fact sheet updated February 2016

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La phagothérapie, une médecine ancestrale pour lutter....

 19 feb 2016
TF1
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Production of Phages for Clinical Trials

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PHAGE THERAPY 2016, Paris

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PhagoBurn Booklet

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BACTERIOPHAGE 2016,London

 

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